The multifunctional calcium/calmodulin-dependent protein kinase, also known as CaM kinase II (CaM KII), is present in high concentration in brain tissue and may play a role in mediating cellular functions. Many long-term potentiation phenomena involved in learning have been attributed to the autophosphorylated form of the enzyme, as it remains active even in the absence of calcium. Promega's Anti-ACTIVE™ CaM KII polyclonal antibody (T286) is specific for the phosphorylated form of the enzyme and can be used in studies requiring highly sensitive detection.
Promega Notes 67, 9.
Said A. Goueli, Martha O'Brien and Kevin Hsiao