PPase-2B Product Information

Literature # 9PIV636

Protein Phosphatase-2B (PPase-2B) is a heterodimeric enzyme composed of a 19kDa calcium-binding subunit and a catalytic subunit (61kDa) that binds calmodulin. PPase-2B is identical to the brain protein calcineurin, which constitutes up to 1% of total brain protein.

PPase-2B is less sensitive to okadaic acid than PPase-2A and PPase-1, requiring micromolar concentrations of okadaic acid for inhibition. It is not inhibited by inhibitor-1 or inhibitor-2. Promega PPase-2B is isolated from bovine brain.